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These outcomes, along with a prior report displaying that a small-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like conduct in mice,2 assist the idea of concentrating on ACKR3 as a singular strategy to modulate the opioid method, which could open new therapeutic avenues for opioid-linked Problems.Tabernaemontana divaricata Conolidine is an ind